Исследователи изучали, почему препараты, подавляющие работу лизосом — структур внутри клетки, отвечающих за переработку веществ и получение энергии, — часто дают лишь ограниченный эффект против опухолей. Оказалось, что раковые клетки способны обходить такую терапию: они усиливают потребление глюкозы и активируют белок SREBP-1, который помогает им перестраивать обмен веществ и продолжать расти.
By 2014, Gates was actively promoting the project. On Sept. 25, he emailed Epstein and Cohen with his schedule for the following week and offered to pitch the fund at the dinner with Dalio and Tudor Jones. The Gates Foundation’s general counsel was working directly with Epstein on the legal structure, the DOJ documents show. But after a breakfast with potential partners that December, Gates pulled back: “I don’t think we have any people at this point who will move to do something soon.”
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Well not today! Today we're making this easy!
But in the years since then, researchers have observed the effect across a wide range of tumor types and animals—beyond mice to zebra fish, fruit flies, and even a few human subjects, with the same protective effect in the brain, lungs, skin, muscle, heart, and bone.